Okay, this is it. The last page before we meet…The Inner Circle! It doesn’t seem fair for me to leave you hanging over the weekend, but I’m doing it anyway.

If you’re looking for a way to waste time this weekend, you can reread the whole story here.

Okay, sports fans, this page was the biggest challenge so far. This one packed a double whammy of difficulty: design and science.

From the design side, I wanted to capture the size of pyruvate dehydrogenase (it is one of the biggest enzymes in nature). I think PD’s magnitude compared to Wilbur and Edna gets this across. I also wanted to illustrate that  this is an enzyme complex that conducts multiple, sequential reactions. To that end PD has three pairs of arms. I tried to capture the sequential aspect by moving from the top set of arms down as the reader moves through the page. The one design element that I really like is that reactants are in the left hand, the the hands come to gether for the enzymatic stuff and the products are in the right hand. Let me know if this works.

As far as the science is concerned, I did my best to get the sets of reaction correct but I’m filled with trepidation. I wanted this to be at no higher level than a text book (and it isn’t even that high) but I want to be as accurate as possible. So, I’m counting all of you with a deeper understanding of the biochemistry and molecular biology of pyruvate dehydrogenase to help me refine and correct. Please chime in below with thoughts and suggestions. (“Good Enoughs” and “Nice Jobs” are also welcome if appropriate).

And now, without any further ado, sit back and enjoy the molecular magic and enzymatic sleight of hand of pyruvate dehydrogenase.

You can read the whole story here.

There are hints of lost love in today’s episode of The Great Respiration Caper. Join Wilbur and Ant Edna for every awkward moment.

To get the full emotional punch of this moment, you can read the whole story here.


It is Transportation Tuesday here at Drawing Flies and we are delighted to bring you an episode that moves the plot along by moving pyruvate right across the membrane.

Frustrated and confused? Read the whole story here and bask in the gentle warming rays of enlightenment. Sorta.

Welcome to Mitochondria Monday! Today Wilbur and Ant Edna dive into the intermembrane space of the mitochondria and have a very positive experience!

Still dragging from the weekend? You can put off doing work for a few more minutes and read the whole story here.

Things get totally cellular for Wilbur and Ant Edna as they make their way to see the mysterious Inner Circle.

Want to catch-up? You can read the whole story here.


It’s a late post today. I apologize to all of you who have been waiting by your computers and constantly updating your browser to see if a new page had been uploaded. But, huzzah! Here’s today’s page and it is full of heartache and smart-alecky behavior.

You can read the whole story here.

Kirkus has posted a review of my forthcoming book Last of the Sandwalkers here. Please check it out and share it with others. It ends thusly:

“…he invests his beetles with tremendous personality, and the dialogue never lags. Though the novel’s a trifle overstuffed, the clarity of its theme and appeal of its characters carry the day. Hosler’s sincere excitement in both the pursuit of knowledge and the power of comics makes these bugs eminently memorable.”


If you like trilobites and veiled threats, then this episode of The Great Respiration Caper is for you!

Want to know how we got to this momentous point in the tale? You can read the whole story here.

In today’s installment, Edna collects the glycolysis pay-off and Wilbur says something stupid.

Confused? You are not alone. It’s tough coming in at the middle. You can read the whole story here.

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